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Psychedelic Definition, Meaning & Synonyms Subsequently, studies from numerous laboratories provided support for that idea, with an initial focus on serotonin 5-HT1A receptors . When serotonin receptor–selective antagonists became available, it was Glennon et al. who demonstrated in a rat drug discrimination model that the 5-HT2 antagonists ketanserin and pirenperone blocked the discriminative cue of a Psychedelic . Further studies in numerous laboratories over the next 2 decades, primarily with rodents, then focused attention on the 5-HT2A receptor as the primary target for psychedelics. Agonist or partial agonist activity at the serotonin 5-HT2A receptor was ultimately concluded to be a necessary pharmacology for psychedelic effects, but it may not be sufficient to explain all of the qualitative differences between different drugs. To use I-Doser, users are instructed to find a comfortable seated or lying down position in a dark room and play the track in headphones. It can ta